In vitro toxicology
The first research track coordinated by Mathieu Vinken is situated in the field of in vitro toxicology. Focus is put on the elucidation of the mechanisms of liver toxicity, in particular of the cholestatic type, using adverse outcome pathway constructs. This is used as the basis for the development and further optimization of liver-based in vitro models for toxicity testing of chemicals from the pharmaceutical, cosmetics, food and biocide sectors.
The second research track supervised by Mathieu Vinken is situated in the field of experimental hepatology. Focus is put on the testing of pannexins, connexins and their cellular channels as targets and biomarkers in liver disease, in particular acute liver failure, cholestasis, non-alcoholic steatohepatitis, liver fibrosis and liver cancer. This is used as the basis for the development and further optimization of novel drugs and diagnostic strategies for the treatment and diagnosis of liver disease.
The third research track led by Mathieu Vinken is situated in the field of space toxicology. Focus is put on the spontaneous occurrence of metabolic dysfunction-associated steatotic liver disease and increased manifestation of hepatotoxic side effects of pharmaceutical drugs in space conditions. This is used as the basis for the establishment of pharmacological countermeasures to protect astronauts' health.
Patent number PCT/EP2004/0012134, WO2006/045331, EP1824965 (B1) applying to United Kingdom, Germany and France, US2009/0130064 (A1) “Differentiation of stem cells and stabilization of phenotypical properties of primary cells”.
Inventors: V. Rogiers, T. Vanhaecke, S. Snykers, P. Papeleu, M. Vinken, G. Elaut and T. Henkens; Applicant: Vrije Universiteit Brussel-Belgium.
Patent number PCT/EP2007/055754, WO2007/144341, EP2041272 (B1) applying to United Kingdom, Germany and France, US2010/278782 (A1) “Differentiation of rat liver epithelial cells into hepatocyte-like cells”.
Inventors: V. Rogiers, T. Vanhaecke, S. Snykers, P. Papeleu, M. Vinken, T. Henkens, E. De Rop, J. Fraczek, J. De Kock and T. Doktorova; Applicant: Vrije Universiteit Brussel-Belgium.
“Anti-inflammatory Panx1 channel inhibitors”, European patent application no. 23158621.5, Applicant: Vrije Universiteit Brussel-Belgium, inventors: M. Vinken, N. Devoogdt, R. Van Campenhout, T.W.M. De Groof.